Tuesday, 24 November 2015

Should Human Cloning Be Legal? by Emily Lauterpacht


In recent years, as technology has advanced, so have our ambitions in how to use it. The first ever clone was created by Hans Adolf Edward Dreisch in 1885, by shaking a sea urchin embryo that was made up of two cells, until they separated, and eventually grew into two separate sea urchins. However, cloning, as we know it today, involves the transfer of the nucleus of one cell into another cell (usually an enucleated egg cell), and the first successful example of this was in 1952, by Robert Briggs and Thomas King. These two men cloned a frog, and found that many attempts at cloning failed. It was also found that some of the clones that did survive grew abnormally. These early difficulties continue to occur regularly, and are amongst the many reasons that the cloning of humans has been so controversial.

Frogspawn
To those who are for human cloning, it represents countless ways that our lives can be improved. It is seen to be a way in which want-to-be parents, who can’t have children, can not only have a child, but have that child be genetically related to them, and in many cases, only them. At the moment, the options for these potential parents are generally limited to adoption, use of a surrogate, in vitro fertilisation (IVF) or artificial insemination, depending on the situation, with the latter two possibly involving sperm and/or egg donors. This means that the child is usually either fully or partly not genetically related to on  or both parents. For many want-to-be parents, these options are far from ideal. The use of human cloning in these situations would mean that couples with fertility problems, or single parents, could have a child that was genetically related to them, and only them, as all of the genetic material only comes from one person, with the potential exception of mitochondrial DNA if the egg used is not that of the person being cloned.
As mentioned earlier, in cloning animals, there have been many issues with growth abnormalities. This has meant that there are very poor survival rates for clones; Dolly the sheep was the only sheep that was born alive out of 277 eggs. Although the statistics have now improved since the time of Dolly’s cloning in 1996, only 2-3 animals survive out of every 100 attempts. However, what worries many people more, is that the animals that do survive to be born have unusually large numbers of deformities. For example, many cloned lambs have breathing problems, as well as enlarged blood vessels (often up to 20 times larger than normal), which put immense amount of stress on the heart. Creating humans who are almost certain to have abnormalities similar to those experienced by cloned animals has huge ethical implications, and is considered the main reason to not legalise human cloning.

Dolly the sheep
Many of those who are for the legalisation of human cloning say that the abnormalities mentioned above can be resolved with practice, and that through learning to successfully clone humans, we will also discover a lot about the ageing process, cell development and cancer. Through developing these areas, we can therefore further our health care abilities. It is also believed that through cloning humans, we could potential use embryonic stem cells from a clone to restore sight, amongst other applications, or we could make brainless clones, which would act as organ donors if the person cloned were ever to need a transplant of any kind.  Were these possible, it would bring yet more ethical issues, which would need to be weighed up against the benefits, which would include no issues of organ rejection, and not having to rely on brain-dead or dead organ donors.
Another issue with human cloning is lack of public understanding. Many members of the public, especially those who feel that human cloning would directly benefit them (for example it may give them the possibly of have a child who is genetically related to them), strongly believe that human cloning should be legal. However, often they do not know all of the facts. For example, while they may be aware of the risk of deformities, they may not realise the potential extent of these, were they able to have a child made by cloning. They therefore blindly battle on, fighting for human cloning, without really knowing what they could get themselves into. Another reason that some people wish to clone humans is so that they may have a dead loved one cloned. Again, this may seem like a lovely idea, but it is predicted that were this to occur, it would have all sorts of detrimental psychological effects, both on the clone, and on the people whose loved one has been cloned. The clone may look like the deceased, but they would have a different personality and different life experiences. Having these feelings and expectations projected onto them as they grow up would likely have negative mental effects on the clone. It would also not bring back the dead, and this is a concept that much of the public, especially when grieving, would likely struggle with. There would also be legal issues with granting permission for the clone to be produced, as clearly, the deceased are unable to consent.

Currently, humans can be cloned if you have a licence, as long as the embryo is destroyed within 14 days, as this is when the nervous system begins to form. The strict laws that regulate this, in my opinion, strike the correct balance in this on going battle between science and ethics. It means that research into, and techniques for cloning are allowed to develop, while not risking the development of foetuses with abnormalities. I strongly believe that it would be wrong to allow the implantations of cloned embryos when there is still such a high risk of serious disabilities – both mental and physical. However, once cloning techniques have been perfected in animals and at these early stages, I believe I will reconsider my stance on the laws on cloning, as these unnecessary and life altering deformities are the part of human cloning that I currently contest.

Emily Lauterpacht

Friday, 13 November 2015

Could fire exist without life? - follow up by Emily Lauterpacht

A few weeks ago I wrote about whether fire could exist without life. In the article (read it here), I concluded that fire would not exist if life didn't, but some recent reading has led me to realise that I was wrong in saying that "fire ... would not be possible, as ... any form of fuel on earth is either alive, has once been alive, or has been modified by humans from something that once was alive". 
Comet Lovejoy has been discovered to be being emitted ethyl alcohol, amongst other organic molecules. In fact, at its peak activity, Comet Lovejoy has been releasing as much alcohol as in at least 500 bottles of wine per second! Some of these organic molecules are flammable, and so, in theory, we have a fuel for fire that exists without life. However, I still stand by my statement that fire couldn't exist without life, as without life, there is still not a sufficient source of oxygen to allow a fire to start.

Comet Lovejoy


Emily Lauterpacht

Tuesday, 3 November 2015

Faecal Microbiota Transplants by Emily Lauterpacht

Faecal microbiota transplants: a disgusting yet intriguing idea, which has taken off in the last few years. 


This seemingly unhygienic practice came into being after a landmark study was published in 2006, about the gut bacteria of mice. It was shown that the gut bacteria of fat and thin mice differ greatly. It also appeared that this was similar to in humans, as when gut bacteria from a thin human was given to a fat mouse, it lost weight, even on the same diet, and if a thin mouse was given fat human gut bacteria, the mouse got fat. 
Soon after this study, this area of research exploded, and soon scientists had found links between the microbes found in human guts and obesity, colon cancer, rheumatoid arthritis, allergies and diabetes. Connections have also been found in mice between their gut bacteria and both depression and multiple sclerosis. 
These discoveries have therefore given rise to faecal microbiota transplants (FMT). The main use for them currently (since 2013) is as a treatment for patients who have been infected with antibiotic resistant Clostridium difficile (C. Difficile). This has led to the survival rate increasing from fewer than a third to 94%.  FMT is now also being used experimentally to treat other conditions (mainly gastrointestinal diseases and neurological conditions) , such as IBS, colitis, chronic diarrhoea, Chronic Fatigue Syndrome and Parkinson's, and now at least 10,000 people in the West have had FMTs. 
This rapidly climbing number has caused  Doctors at the Massachusetts Institute of Technology to open the first and largest "stool bank" in the world, OpenBiome. Here, donors' faeces are screened, anonymised, given code names (for example Professor Dumpledore and Vladimir Pootin), and then usually shipped to hospitals or other institutes to be studied. 
To find out more about FMT and OpenBiome, see their website here

Emily Lauterpacht